Two sample MR report
CDC42_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.0388486 | 0.0607694 | 0.5405107 |
| Weighted median | 10 | -0.0253819 | 0.0100272 | 0.0113639 |
| Inverse variance weighted | 10 | -0.0272285 | 0.0081615 | 0.0008493 |
| Simple mode | 10 | -0.0239088 | 0.0154180 | 0.1553858 |
| Weighted mode | 10 | -0.0243635 | 0.0152090 | 0.1436382 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4655869 | 8 | 0.9998983 |
| Inverse variance weighted | 0.5028218 | 9 | 0.9999688 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0064934 | 0.0336509 | 0.8517964 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001597 | 0 | TRUE | 0.2304408 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
